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Error:
update-initramfs: Generating /boot/initrd.img-3.0.0-12-generic
Warning: No support for locale: en_US.utf8

Issue:
The problem is that /usr/share/initramfs-tools/hooks/root_locale is expecting to see individual locale directories in /usr/lib/locale, but locale-gen is configured to generate an archive file by default.

Fix:

# locale-gen --purge --no-archive
Generating locales...
en_AG.UTF-8... done
en_AU.UTF-8... done
en_BW.UTF-8... done
en_CA.UTF-8... done
en_DK.UTF-8... done
en_GB.UTF-8... done
en_HK.UTF-8... done
en_IE.UTF-8... done
en_IN.UTF-8... done
en_NG.UTF-8... done
en_NZ.UTF-8... done
en_PH.UTF-8... done
en_SG.UTF-8... done
en_US.UTF-8... done
en_ZA.UTF-8... done
en_ZM.UTF-8... done
en_ZW.UTF-8... done
Generation complete.

# dpkg-reconfigure locales
Generating locales...
en_AG.UTF-8... done
en_AU.UTF-8... done
en_BW.UTF-8... done
en_CA.UTF-8... done
en_DK.UTF-8... done
en_GB.UTF-8... done
en_HK.UTF-8... done
en_IE.UTF-8... done
en_IN.UTF-8... done
en_NG.UTF-8... done
en_NZ.UTF-8... done
en_PH.UTF-8... done
en_SG.UTF-8... done
en_US.UTF-8... up-to-date
en_ZA.UTF-8... done
en_ZM.UTF-8... done
en_ZW.UTF-8... done
Generation complete.